| Product name |
Boluoke® |
Nattokinase |
Boluoke® Imitators |
Serrapepti-dase |
Bromelain |
| Packaging |
60 capsule |
60-90 caps (varies) |
30-36 caps |
60-90 tabs |
60-100 tabs |
| Main ingredient amount |
20mg lumbrokinase per cap |
36-100mg nattokinase per cap mostly |
230-250mg of earthworm extract per cap |
5 or 10mg of serrapepti-dase per cap |
250-500mg bromelain per cap |
| Retail price (in USD) |
$92.76 |
~$60.00 |
~$36.95 |
$13.95-$18.95 |
$13.50-$22.50 |
| Enteric coated |
Yes |
Some |
Some |
Some |
No |
| Dosage |
1 cap 1-3 times daily for maintenance or 2 caps 3 times daily for 3 weeks |
100mg/d for maintenance or 300mg/d acutely |
4 capsules daily; or 6 to 9 capsules daily |
1-2 caps 3 times daily |
750-2000mg daily or higher |
| Enzyme source |
Earthworms |
Natto cheese |
Earthworm |
Silkworm |
Pineapple stem |
| Enzyme composition |
A multiple enzyme preparation |
A single enzyme preparation |
A multiple enzyme Preparation |
A single enzyme preparation |
A single enzyme preparation |
| Suitable for strict vegetarians |
No |
Yes |
No |
No |
Yes |
| Enzyme is standardized against Urokinase & t-PA activies |
Yes. Each mg of lumbrokinase in Boluoke contains no less than 120,000u of tPA activity, and no less than 100u of Urokinase activity |
No. But 1mg of cDNA nattokinase (95% pure) contains ~12,000u of tPA* activity (commercial nattokinase is much weaker) |
Unknown |
A proteolytic enzyme, but not a true fibrinolytic agent |
A proteolytic enzyme, but not a true fibrinolytic agent |
| Commonly used in clinics anywhere in the world |
Yes, used in many China hospitals/clinics since 1995 |
No. |
N/A |
N/A |
N/A |
| Effects on PT or APTT |
Boluoke® does not signif. affect PT or APTT |
Possibly if Vit. K was not removed |
Yes |
Unknown |
Markedly prolong PT and APTT |
| Inhibits platelet aggregation |
Yes |
Yes |
Unknown |
No |
No |
| Human clinical trials done |
Yes. Phase I to III clinical trials completed on Boluoke® in China |
Some small (less than 30 subjects) human trials |
Unkown |
Mainly on tissue/lung inflammation |
Mainly on tissue inflammation |
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